In a nut shell here’s what it comes down to. Tone, it seems to be what we’re after. Be prepared to go through several dozen brands of strings and string gages. What works for one guitarist may not give you the tone you are looking for. Your set up may be different in several ways; you may have a different guitar, different pick ups, different amp or even different pedals or effects.
There are no easy answers for strings. So I’ll let you do some reading about them. Here’s a couple of links that may be helpful to you. Check out the FAQs at the GHS web site. There is some good basic information there. The other site I recommend looking at is Professor String . You could spend the better part of a couple days reading what’s on their site, but you’ll get so much info your brain will explode.
Good luck and don’t get too wound up.